Figure 18. Number of females is more than males
An
acute attack are more commonly occur in women population than men, and it
happens rarely before puberty and after menopause as well (Sassa, 2006). It had supported a strong endocrine
influence, which it more likely to happen when women experienced premenstrual
hormonal changes or pregnancy. Innala et al. (2012) study have supported this point of
view. They found that women with AIP showed a relatively lower level of serum
concentration in terms of allopregnanoloce when compared to normal women, while
the most significant differences was in the luteal phase of menstrual cycle (Innala, Backstrom, Poromaa,
Andersson, & Bixo, 2012). These patients break down hormones
in an abnormal ways and produce more porphyrins.
On the other hand, study also showed that pregnancy also potentially exacerbate acute attack (Tollanes , Aarsand, & Sandberg, 2010). It raises an excess risk for the AIP to have a low weight birth, premature delivery, perinatal death, congenital malformations and also other adverse outcomes (Andersson, Innala, & Backstrom, 2003). Rather, women with AIP should be monitored carefully during pregnancy. All in all, usually combination of these factors works in triggering an attack.
On the other hand, study also showed that pregnancy also potentially exacerbate acute attack (Tollanes , Aarsand, & Sandberg, 2010). It raises an excess risk for the AIP to have a low weight birth, premature delivery, perinatal death, congenital malformations and also other adverse outcomes (Andersson, Innala, & Backstrom, 2003). Rather, women with AIP should be monitored carefully during pregnancy. All in all, usually combination of these factors works in triggering an attack.
Figure 19. Pregnancy
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